Used folic acid and there was no change in folic acid serum levels, started using 5-MTHF daily and serum levels increased within 2 weeks so that I had to switch to supplementing once every 2-3 days. Note, that everybody's different, so for somebody else folic acid my work as well. For me - 5-MTHF.

I have the 5-MTHF mutation, and taking these have literally changed my life. I have so much more energy than I think I've ever had and have gone from a disability pension to working 4 days a week. If you have that mutation it's definitely worth giving these a go!

This one's the best thing to take especially for pregnant (and trying-to-get-preggy) women. I've been diagnosed with the MTHFR mutation gene and I wish I had known about it before my first pregnancy. My new OB highly recommends this one. This brand also comes up as one of the best options out there. Value for money and very good.

5-MTHF is the best form of folic acid and may be taken during pregnancy (please, never take a synthetic form). It plays an essential role in methylation, it enables the conversion of homocysteine to methionine, the production of serotonin and melatonin, and it is indirectly involved in the synthesis of DNA. It also helps with depression, megaloblastic anemia, and renal and hepatic impairment. Thorne is a solid brand but very expensive.

5-MTHF is a natural and active form (please, never take synthetic folic acid, it doesn't give you any benefits but may be harmful).It is more effective than folic acid at increasing serum active folate levels, it is the best form of folate required for lowering dangerous homocysteine levels. The human body needs folate to perform many functions, including cell division, growth, and the production of new red blood cells. It could help improve the language and communication skills of children with ASD. I take it with DMG and big doses of MB12 to help with methylation.

I was referred this product by my Kinesiologist. I have been taking this brand for approximately nine months & haven't had any noticeable negative side effects. I definitely see improvements in my overall mental health from these. I love that Thorne is GF and these pills are tiny making them easy to swallow. Great Product, Super Fast shipping!

High quality brand and product with low and clean other non-active ingredients/exipients, you can always depend on Thorne for that. This is the best form of folate to take as folate needs to be methylated in the body and some people can't effectively methylate folic acid if taken in that form as a supplement. Also important as having high levels of un-converted folic acid in your system can be deleterious.

Activated folic acid is an absolute must when pregnant, as well as a fertility booster when trying to conceive. Thorne's is, of course, of best quality (and that's exactly what one wants for their baby). The small-in-size capsules are easy to swallow, have no taste or smell. Highly recommend.

Thorne is always reliable for quality supplements and this one does what I bought it for - improving mood and overall energy, without creating a feeling of being wired or anxious like a lot of 'energy' supplements can do. I started with a lower dose and found it's enough for me.

To me, the test for whether a supplement does its job is whether I feel any better after taking it. I feel better after taking this, no adverse reactions and have the confidence which comes with knowing I am taking a very good quality supplement. Please like my review if you found it helpful.